tag:blogger.com,1999:blog-4756081185218551951.post6927018249150906210..comments2019-02-19T07:43:51.975+05:30Comments on Pharma Engineering: Scale-Up of process equipment's in PharmaAjay Kumarhttp://www.blogger.com/profile/14369498840043320777noreply@blogger.comBlogger4125tag:blogger.com,1999:blog-4756081185218551951.post-83441448171113809472019-02-13T20:08:10.164+05:302019-02-13T20:08:10.164+05:30How can i correlate the agitatorHow can i correlate the agitatorseetha ramaiahhttps://www.blogger.com/profile/10390651765878520742noreply@blogger.comtag:blogger.com,1999:blog-4756081185218551951.post-52138694322975943372019-02-13T20:06:44.472+05:302019-02-13T20:06:44.472+05:30Dear Aajay very good information
let me know, cry...Dear Aajay very good information<br /><br />let me know, crystallization doing anchor agitator, now we are changing the agitator to propeller ok can we get same results after calculating the p/v valve seetha ramaiahhttps://www.blogger.com/profile/10390651765878520742noreply@blogger.comtag:blogger.com,1999:blog-4756081185218551951.post-27350409117518152192019-02-12T06:24:21.731+05:302019-02-12T06:24:21.731+05:30Dear Viswam,
What you said is correct, and above ...Dear Viswam,<br /><br />What you said is correct, and above i've mentioned about only for maintaining the consistent purity and the alpha calculation can replicate the rate of filtration, as in lab there will be suction from bottom of buckner, so i've skipped the rate of filtration, however i'll try to extend the post.<br />As you asked in centrifuge there will be centrifugal force in action, hence the pressure applied in lab shall be equated to centrifuges RPM as like below,<br /><br />Pressure = Centrifugal force / filtration Area = m x r x N^2 / A<br /><br />m - mass of the wet cake, r is the radius of the basket, N is the rpm of the centrifuge,<br />A is the area of the perforated filtration area.<br /><br />If any queries feel free to comment.<br /><br />Best Regards,<br />AJAY KAjay Kumarhttps://www.blogger.com/profile/14369498840043320777noreply@blogger.comtag:blogger.com,1999:blog-4756081185218551951.post-75378997266701196052019-02-12T03:30:04.993+05:302019-02-12T03:30:04.993+05:30Thanks for sharing good technical info
Regarding s...Thanks for sharing good technical info<br />Regarding scale up in filtration,<br />In labs we use Buchner funnel in which constant pressure filtration technique is applicable,<br />If we plan a pnf or anf <br />Simply from the graph of t/V Vs V we can calculate alpha,Rm <br />With this we can calculate filtration time but<br />If we plan centrifuge in plant, filtration takes place on basis of centrifugal separation then<br />How to correlate the data from lab to plant<br /><br />Regards,<br />Viswanath.Viswamhttps://www.blogger.com/profile/06365778452514972964noreply@blogger.com